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Elucidating nuclear reprogramming mechanisms

While conservation reserves have been established and population numbers of the giant panda have recently increased, The giant panda was widely distributed in China and south-eastern Asia during the middle to late Pleistocene, prior to its habitat becoming rapidly reduced in the Holocene.While conservation reserves have been established and population numbers of the giant panda have recently increased, the interpretation of its genetic diversity remains controversial.Using pharmacological perturbation, we further uncovered a role of glycogen synthase kinase 3 (GSK3) in WNT5A regulation of KIF26B degradation.Lastly, based on the identification of the WNT5A-responsive domain, we developed a new reporter system that allows for efficient profiling of WNT5A-KIF26B signaling activity in both somatic and stem cells.The results showed that the dwarf Jingxing-Huang (JXH) chicken was more susceptible to fatty liver compared with the layer White Leghorns (WL) and local Beijing-You (BJY) breeds.In addition, it was found that the paternal fatty livers induced by HF diet in JXH chickens were inherited.Compared to birds without fatty liver in the control group, both offsprings and their sires with fatty livers in the paternal group exhibited altered hepatic gene expression profiles, including upregulation of several key genes involved in fatty acid metabolism, lipid metabolism and glucose metabolism (ACACA, FASN, SCD, ACSL5, FADS2, FABP1, APOA4 and ME1).

Xenopus embryos are also amenable to large-scale screening, but Xenopus laevis embryos are an established model for studying kidney development.

In the current study, fatty Fatty liver is a widespread disease in chickens that causes a decrease in egg production and even death.

In the current study, fatty liver was induced in 3 breeds by a high-fat (HF) diet and a methionine choline-deficient (MCD) diet.

In conclusion, our study identifies a new protein domain that mediates WNT5A-dependent degradation of KIF26B and provides a new tool for functional characterization of noncanonical WNT5A signaling in cells.

Full article Metabolic reprogramming is an important issue in tumor biology.

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  2. Kwang-Soo Kim, PhD is the director of Molecular Neurobiology Laboratory.

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