In February 2014, Bakula was cast as the lead in a backdoor pilot for the current NCIS spin-off series, NCIS: New Orleans, which began as a two-part episode of its parent series in the spring season of 2014.
The third season of NCIS: New Orleans premiered on September 20, 2016.
He currently portrays Dwayne Pride on NCIS: New Orleans.
Bakula moved to New York City in 1976, where he made his Broadway debut playing baseball legend Joe Di Maggio in Marilyn: An American Fable, and appeared in the well-received Off-Broadway production Three Guys Naked from the Waist Down; he would later appear in its Pasadena Playhouse production.
In April 2009, he began a recurring role on the television series Chuck as Stephen J.
He is best known for his roles in the sci-fi televison series Star Trek: Enterprise and Quantum Leap.
In 2016 Bakula appeared as a guest judge on the HGTV show Brothers Take New Orleans with Property Brothers Jonathan and Drew Scott.
He made a cameo appearance on the season 12 opener of It's Always Sunny in Philadelphia as himself.
Beginning in December 2009, Bakula began appearing as Terry, one of the three lead characters, along with Ray Romano (Joe) and Andre Braugher (Owen), in TNT's hour-long comedy/drama Men of a Certain Age.
In 2011, Bakula performed a voice cameo in the film Source Code as a slight nod to his character on Quantum Leap, with his catchphrase of "Oh, boy." and appeared in the feature-length documentary The Captains, which was written and directed by William Shatner, Bakula is interviewed by the original Star Trek captain about his life and career leading up to his performances as Captain Jonathan Archer in Star Trek: Enterprise.