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namely difficulty falling asleep, frequent awakening, early awakening, or a combination of each.

Nitrazepam is sometimes tried to treat epilepsy when other medications fail.

It has been found to be more effective than clonazepam in the treatment of West syndrome, which is an age-dependent epilepsy, affecting the very young.

In uncontrolled studies, nitrazepam has shown effectiveness in infantile spasms and is sometimes considered when other anti-seizure drugs have failed.

Nitrazepam rapidly crosses the placenta and is present in breast milk in high quantities.Increased levels of GABA in cerebral tissue and alterations in the activity state of the serotoninergic system occur as a result of nitrazepam tolerance.Nitrazepam can cause dependence, addiction, and benzodiazepine withdrawal syndrome.Withdrawal from nitrazepam may lead to withdrawal symptoms which are similar to those seen with alcohol and barbiturates.Common withdrawal symptoms include anxiety, insomnia, concentration problems, and fatigue.More common side effects may include: Central nervous system depression, including somnolence, dizziness, depressed mood, fatigue, ataxia, headache, vertigo, impairment of memory, impairment of motor functions, hangover feeling in the morning, slurred speech, decreased physical performance, numbed emotions, reduced alertness, muscle weakness, double vision, and inattention have been reported.Unpleasant dreams and rebound insomnia have also been reported.The side effects of nitrazepam may impair the development of motor and cognitive skills in children treated with nitrazepam.Withdrawal only occasionally resulted in a return of seizures and some children withdrawn from nitrazepam appeared to improve.Breast feeding by mothers using nitrazepam is not recommended.Nitrazepam is a long-acting benzodiazepine with a risk of drug accumulation, though no active metabolites are formed during metabolism.


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