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The fictional series focuses on the lives of surgical interns, residents, and attending physicians, as they develop into seasoned doctors while trying to maintain personal lives and relationships.The title is a play on Gray's Anatomy, a classic human anatomy textbook first published in 1858 in London and written by Henry Gray.

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Other additions include Leah Murphy (Tessa Ferrer), who departs near the end of the tenth season, but returns during the thirteenth; Shane Ross (Gaius Charles), who departs with Yang in the tenth-season finale; Stephanie Edwards (Jerrika Hinton), who resigns during season thirteen; Jo Wilson (Camilla Luddington), a doctor who begins a romantic relationship with Karev; Andrew Deluca (Giacomo Gianniotti), the love-interest of Meredith's half-sister Maggie Pierce (Kelly Mc Creary), who also serves as head of cardio; and Benjamin Warren (Jason George), an anesthesiologist-turned-resident, who has to balance his own desire to succeed with his wife Miranda Bailey's new role as Chief of Surgery.Since its inception, the show has been described by the media outlets as a television "phenomenon" or a "juggernaut", owing to its longevity and dominant ratings.It is considered to have had a significant effect on popular culture and has received numerous awards, including the Golden Globe Award for Best Television Series – Drama.Grey's Anatomy is the longest-running scripted primetime show currently airing on ABC, the second-longest scripted primetime ABC show ever, and the second-longest primetime medical drama, after ER.The series follows Meredith Grey (Ellen Pompeo), the daughter of an esteemed general surgeon named Ellis Grey, following her acceptance into the residency program at the fictional Seattle Grace Hospital.[...] My sisters and I would call each other up and talk about operations we'd seen on the Discovery Channel.There's something fascinating about the medical world—you see things you'd never imagine, like the fact that doctors talk about their boyfriends or their day while they're cutting somebody open.In addition to Webber, Burke, and Shepherd, the surgical wing is primarily supervised by Addison Montgomery (Kate Walsh), as head of OB/GYN, neonatal, and fetal surgery; Callie Torres (Sara Ramirez), a resident who later becomes head of orthopedic surgery, who left Seattle at the end of the twelfth season; Mark Sloan (Eric Dane), as head of plastics; Owen Hunt (Kevin Mc Kidd), as head of trauma; Arizona Robbins (Jessica Capshaw), as head of pediatric surgery, and later head of fetal surgery; Erica Hahn (Brooke Smith), as head of cardio; Teddy Altman (Kim Raver), as head of cardio; and Amelia Shepherd (Caterina Scorsone), Derek's sister, who is hired to replace him as head of neuro.New young doctors in the residency program include Lexie Grey (Chyler Leigh), Meredith's half-sister.So when ABC asked me to write another pilot, the [operating room] seemed like the natural setting."[m]edical shows are hard, and it was hard trying to figure out where ours could be different.

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